Computer Vision News - October 2019

Project by RSIP Vision - Multiplex 30 Multiplex immunohistochemistry is a staining technique targeting multiple markers within the same tissue slice. W h a t i s M u l t i p l e x immunohistochemistry? Why do we need multiple stains? The main motivation behind the idea of multiplex is twofold: it supplies detailed information regarding specific individual cells while maintaining the spatial structure of the tissue. This allows gaining insight into the single cell protein expression profile combined with information regarding the interaction with other cells within the tissue. This process maximizes the amount of information extracted from individual samples. Which types of automated analyses can be performed on these slides? Over the last few years the fields of deep-learning and computer vision have undergone a significant progress. Together with the significant progress in the fields of microscopic scanners and digital pathology, allowing the acquisition of high-resolution whole slide images, and in the field of molecular biology, allowing targeting multiple specific markers in the same tissue slide, we are able to perform detailed and highly accurate analysis in the levels of single cells and tissue. For example, we can performa detection and segmentation of single cells and classify them into different cell types by their protein expression profile. We are also able to localize them and map their interaction with other cell types. In addition, it is possible to identify different tissue types, for example- normal and malignant tissues, different types of tumors, etc. these analyses can be used for both research and diagnostic purposes. What is special in RSIP Vision’s approach to Multiplex? RSIP Vision’s work consists of state- of-the-art deep learning techniques by Dorin Yael

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